• Genome-Wide Reconstruction of Rediploidization Following Autopolyploidization across One Hundred Million Years of Salmonid Evolution 

      Gundappa, Manu Kumar; To, Thu-Hien; Grønvold, Lars; Martin, Samuel A. M.; Lien, Sigbjørn; Geist, Jürgen; Hazlerigg, David; Sandve, Simen Rød; Macqueen, Daniel J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      The long-term evolutionary impacts of whole-genome duplication (WGD) are strongly influenced by the ensuing rediploidization process. Following autopolyploidization, rediploidization involves a transition from tetraploid to diploid meiotic pairing, allowing duplicated genes (ohnologs) to diverge genetically and functionally. Our understanding of autopolyploid rediploidization has been informed ...
    • Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics 

      West, Alexander Christopher; Mizoro, Yasutaka; Wood, Shona; Ince, Louise M.; Iversen, Marianne; Jørgensen, Even Hjalmar; Nome, Torfinn; Sandve, Simen Rød; Martin, Samuel A. M.; Loudon, Andrew S. I.; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-04)
      Anadromous salmonids begin life adapted to the freshwater environments of their natal streams before a developmental transition, known as smoltification, transforms them into marine-adapted fish. In the wild, smoltification is a photoperiod-regulated process, involving radical remodeling of gill function to cope with the profound osmotic and immunological challenges of seawater (SW) migration. While ...
    • Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar) 

      Iversen, Marianne; Mulugeta, Teshome Dagne; West, Alexander Christopher; Jørgensen, Even Hjalmar; Martin, Samuel A. M.; Sandve, Simen Rød; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-12)
      The developmental transition of juvenile salmon from a freshwater resident morph (parr) to a seawater (SW) migratory morph (smolt), known as smoltification, entails a reorganization of gill function to cope with the altered water environment. Recently, we used RNAseq to characterize the breadth of transcriptional change which takes place in the gill in the FW phase of smoltification. This highlighted ...